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Year : 2023  |  Volume : 3  |  Issue : 1  |  Page : 11-13

An atypical presentation of dermatomyositis sine dermatitis

1 Department of Medicine, ABVIMS and Dr. RML Hospital, New Delhi, India
2 Department of Pathology, GB Pant Hospital, New Delhi, India

Correspondence Address:
Dr. Garyll Ryan Tariang Blah
Department of Medicine, ABVIMS and Dr. RML Hospital, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ara.ara_15_22

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Dermatomyositis (DM) is a rare autoimmune disorder. This idiopathic inflammatory myopathy (IIM) is characterized by overexpression of major histocompatibility complex I and the formation of autoantibodies. Apart from muscle weakness, dermatological involvement is classically seen in DM. Recently, a few articles have been published documenting a subset of DM with no skin involvement – DM sine dermatitis. Here, we present a 37-year-old male with progressive proximal weakness with no skin involvement. Unlike classical DM, neither muscle enzymes (creatinine phosphokinase and aldolase) were elevated nor myositis-specific autoantibodies were detected. Muscle biopsy, however, was characteristic for DM with positivity for CD3, CD4, CD8, CD20, and CD68. The patient improved with initiation of immunosuppressants. Screening for malignancy and interstitial lung disease was unremarkable.

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